Publications
Selected publications
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ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors.
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Mainwaring O*, Weishaupt H*, Zhao M, Rosén G, Borgenvik A, Breinschmid L, Veerbaan AD, Richardson S, Thompson D, Clifford SC, Hill RH, Annusver K, Sundström A, Holmberg KO, Kasper M, Hutter S and Swartling FJ.
Nature Comms. 2023, 14(1):1221. -
Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas.
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Weishaupt H*, Čančer M*, Rosén G, Holmberg KO, Häggqvist S, Ignas Bunikis, Jiang Y, Sreedharan SS, Gyllensten U, Becher OJ, Uhrbom L, Ameur A, Swartling FJ.
Neuro-Oncology. 2023, 25(1):97-107. -
Dormant SOX9-positive cells facilitate MYC-driven medulloblastoma recurrence.
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Borgenvik A*, Holmberg KO*, Bolin S*, Zhao M, Savov V, Rosén G, Hutter S, Garancher A, Rahmanto AS, Bergström T, Mainwaring O, Rusert J, Sundström A, Ballester Bravo M, Richardson S, Fotaki G, Hill RM, Dubuc A, Kalushkova A, Remke M, Čančer M, Jernberg-Wiklund H, Giraud G, Sangfelt O, Taylor MD, Clifford SC, Schüller U, Wechsler-Reya RJ, Weishaupt H and Swartling, FJ.
Cancer Res. 2022, 82(24):4586-4603. -
Medulloblastomics revisited: biological and clinical insights from thousands of patients.
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Hovestadt V, Ayrault O, Swartling FJ, Robinson GW, Pfister SM, Northcott PA.
Nat Rev Cancer. 2020, 20(1):42-56. -
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.
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Čančer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, Bergström T, Garancher A, Essand M, Wechsler-Reya RJ, Falk A, Weishaupt H, Swartling FJ.
Cell Stem Cell. 2019, 25(6):855-870.e11. -
Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes.
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Weishaupt H, Johansson P, Sundström A, Lubovac-Pilav Z, Olsson B, Nelander S and Swartling FJ.
Bioinformatics. 2019, 35(18):3357-3364. -
Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
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Bolin S, Borgenvik A, Persson CU, Sundström A, Qi, J, Weiss WA, Cho J-Y, Bradner, JE, Weishaupt H, Swartling FJ
Oncogene 2018, 37:2850-2862. -
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.
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Suryo Rahmanto A*,1, Savov V*, Brunner AW, Bolin S, Weishaupt H, Čančer M, Rosén G, Hutter S, Sundström A, Kawauchi D, Jones DT, Spruck C, Taylor MD, Maljukova A, Cho YJ, Pfister SM, Kool M, Korshunov A, Swartling FJ*# and Sangfelt O*#.
EMBO J. 2016, 35:2192-2212. -
Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC.
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Swartling FJ#, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA#.
Cancer Cell. 2012, 21(5):601-13. -
Pleiotropic role for MYCN in medulloblastoma.
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Swartling FJ*, Grimmer MR*, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Collins R, Nguyen K, Yakovenko S, Zhe XN, Flynn Gilmer HC, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA# and Chesler L#.
Genes & Dev. 2010, 24:1059-72.